Comprehensive GI care from fellowship-trained specialists. From routine colonoscopy to advanced ERCP — over 20,000 procedures and counting. Two convenient locations.
Full-spectrum diagnostic and therapeutic services for all GI conditions — from screening colonoscopy to complex interventional procedures
State-of-the-art colon cancer screening and polyp detection using the latest HD endoscopic technology. Early detection saves lives.
Learn More →Advanced examination and treatment of esophageal, stomach, and duodenal conditions with high-definition imaging.
Learn More →Specialized bile duct and pancreatic duct procedures. Dr. Saini trained directly under ERCP pioneers at Mount Sinai/Beth Israel.
Learn More →Comprehensive management of inflammatory bowel disease including biologic therapies and personalized treatment plans.
Learn More →Expert diagnosis and treatment of chronic heartburn, esophageal disorders, and Barrett's esophagus.
Learn More →Evaluation and management of hepatitis, fatty liver disease, cirrhosis, and abnormal liver function tests.
Learn More →Personalized strategies for irritable bowel syndrome, bloating, abdominal pain, and motility disorders.
Learn More →Non-invasive small bowel imaging — Dr. Saini was among the first in OC to offer video capsule endoscopy (since 2002).
Learn More →Access cutting-edge treatments through our active GI clinical research program. Novel therapies at no cost to qualifying patients.
Learn More →Fellowship-trained, board-certified specialists with decades of combined experience
"The best GI doctor in Orange County"— Dr. Robert Egan, Personal Physician to John Wayne, who entrusted his practice to Dr. Saini upon retirement
A child prodigy who ranked first in statewide examinations in Punjab, India at age 11, Dr. Saini was admitted to college at 15 and earned a merit scholarship to the prestigious Government Medical College, Amritsar at just 16. He graduated at 21 with Gold Medals in both Medicine and Pharmacology — achievements that launched a career of relentless excellence.
Dr. Saini came to England and pursued post-graduate Internal Medicine training, becoming a Licentiate of the Royal College of Physicians, London. During this training, he fell in love with the subspecialty of Gastroenterology. He then moved to New York City, where he was accepted into the highly competitive GI fellowship at Mount Sinai School of Medicine / Beth Israel Medical Center — then one of the world's premier programs for hands-on endoscopic training. There, he had the rare privilege of training one-on-one under Dr. Hiromi Shinya, the physician who helped design the modern colonoscope and whose landmark studies of colon polyps at Beth Israel became the scientific foundation for screening colonoscopy to prevent colon cancer. Dr. Saini also trained under Dr. Jerome Siegel and more than 30 of New York City's top gastroenterologists, with special expertise in therapeutic ERCP.
Dr. Saini has been in private practice at Fashion Island, Newport Beach since 1998 and has performed over 20,000 colonoscopies with an outstanding safety record. In 2004, Dr. Robert Egan — renowned physician to legendary actor John Wayne — chose to pass his practice on to Dr. Saini after observing his work at Hoag Hospital, where Dr. Saini served as Chairman of the GI Division. Dr. Egan continues to endorse our practice to his former patients to this day.
After 44 years of visiting many doctors, Dr. Saini was the best experience. He was so caring, professional, knowledgeable and polite and answered all my concerns.
— Verified Patient Review
Dr. Hughes is a talented, rigorously trained gastroenterologist who earned his place in medical school on a merit scholarship — a testament to his academic distinction and commitment to medicine from an early stage in his career.
After completing his gastroenterology fellowship, Dr. Hughes spent his first two years in clinical practice in Phoenix, Arizona, where he honed his skills across the full spectrum of GI care — from diagnostic and screening colonoscopy to managing complex conditions like inflammatory bowel disease and liver disorders.
Now part of our team in Orange County, Dr. Hughes combines contemporary, evidence-based training with genuine compassion for every patient. He is dedicated to staying at the forefront of gastroenterology through continuing education and clinical research, ensuring his patients benefit from the latest advances in the field.
Rated 4.9 out of 5 stars on Google — see why thousands of patients trust our team
"After 44 years of visiting many doctors, Dr. Saini was the best experience. He was so caring, professional, knowledgeable and polite and answered all my concerns."
"Dr. Saini and his staff are wonderful. The office is well-run and the care is excellent. I recommend him without reservation to anyone needing GI care."
"Professional, thorough, and reassuring. Dr. Saini took the time to explain everything and made sure I was comfortable. Highly recommend this practice."
"Best gastroenterologist I've ever visited. The entire team is organized, efficient, and genuinely caring. My colonoscopy experience was excellent."
"Dr. Saini is incredibly knowledgeable and takes the time to answer every question. The office staff is friendly and the wait time is minimal."
"Found Dr. Saini through a referral and so glad I did. He diagnosed my issue quickly when others couldn't. Truly one of the best in Orange County."
Dr. Saini has called Orange County home for 28 years. He's not just your gastroenterologist — he's your neighbor. That's why thousands of local families trust our practice across Newport Beach, Fountain Valley, Costa Mesa, Irvine, Huntington Beach, and beyond.
Find us on Nextdoor for health tips, community updates, and answers to your GI questions from a doctor who lives and practices right here in your neighborhood.
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After 28 years in gastroenterology, I've learned that high-quality supplements can make a real difference in digestive health. I only recommend professional-grade products that I trust for my own family.
— Dr. Surinder SainiThird-party tested for purity and potency
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Access innovative treatments before they become widely available
Investigational medications not yet FDA-approved
Study medications and care at no charge to participants
Enhanced oversight and frequent follow-up
Help improve treatments for future patients
Interested in participating? Contact our research coordinator.
Inquire About Trials Call Research TeamTwo convenient locations serving Orange County
Monday – Friday: 8:00 AM – 5:00 PM
Saturday: 9:00 AM – 1:00 PM
Sunday: Closed
As a Medicare beneficiary, you have certain rights and protections. We are committed to providing you with the information you need regarding your Medicare coverage and our billing practices. Please contact our billing department at (949) 650-5155 or visit Medicare.gov for more information about your benefits.